ABSTRACT This study assesses the anti-arthritic effect of the affinin-enriched (spilanthol, main alkamide) hexane extract from the roots of Heliopsis longipes (A. Gray) S.F. Blake, Asteraceae, on a Freund adjuvant-induced arthritis model in rodents. The extract was orally administered at a dose of 2, 6.6, or 20 mg/kg; a significant edema-inhibitory activity in the acute and chronic phases was observed with a dose of 2 and 20 mg/kg, respectively. The extract showed higher anti-inflammatory and anti-arthritic effects than the reference drug phenylbutazone (80 mg/kg). Moreover, the extract prevented the occurrence of secondary lesions associated to this pharmacological model.

The diastereoselective synthesis of bicyclic lactams (-)-(3R,6S,8aS)-6-methyl- and -6-ethyl-3-phenyl-hexahydrooxazolo[3,2-a]pyridin-5-ones 4(a-b) and (-)-(3R,6R,8aS)-6-methyl-3-phenyl-hexahydrooxazolo[3,2-a]pyridin-5-one 4'a are described.

Se describe la síntesis diasteroselectiva de las biciclo lactamas (-)-(3R,6S,8aS)-6-metil- y -6-etil-3-fenil-hexahidrooxazolo[3,2-a]piridin-5-onas 4(a-b), y la (-)-(3R,6R,8aS)-6-metil-3-fenil-hexahidrooxazol[3,2-a]piridin-5-ona 4'a.